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- Slaughter
- Slaughterhouse
- Slayer
- Sleeper
- Slick Rick
- Slick Shoes
- Slightly Stoopid
- Slim Thug
- Slim Whitman
- Slipknot
- Sloan
- Slobberbone
- Slowdive
- Slum Village
- Sly & the Family Stone
- Small Faces
- Smash Mouth
- Smashing Pumpkins
- Smile Empty Soul
- Smokey Robinson
- Smokie
- Smoking Popes
- Sneaker Pimps
- Snog
- Snoop Dogg
- Snow
- Snow Patrol
- Snuff
- So They Say
- Social Distortion
- Soda Stereo
- Sodastream
- Sodom
- Soft Cell
- Softies
- Soil
- Soilwork
- Solange
- Solitude Aeturnus
- Solomon Burke
- Something for Kate
- Son Volt
- Sonata Arctica
- Sondre Lerche
- Songs: Ohia
- Sonic Youth
- Sonny & Cher
- Sonny Boy Williamson I
- Sonny Boy Williamson II
- Sonny Criss
- Sonny James
- Sonny Rollins
- Sonny Stitt
- Sons of the Desert
- Sophie Ellis-Bextor
- Sophie Milman
- Sophie Zelmani
- Soraya
- Soul Asylum
- Soul Coughing
- Soul Decision
- Soulfly
- Soulwax
- Soundalikes
- Soundgarden
- South
- South Central Cartel
- Southside Johnny
- Space
- Sparkle
- Sparklehorse
- Sparks
- Sparta
- Spearhead
- Special Ed
- Spectrum
- Spice 1
- Spice Girls
- Spike Jones
- Spike Robinson
- Spin Doctors
- Spinal Tap
- Spineshank
- Spirit
- Spirit of the West
- Spiritual Beggars
- Spiritualized
- Splender
- Split Enz
- Spock's Beard
- Sponge
- Spoon
- Sportfreunde Stiller
- Spunge